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Professor Zhen Qiu

Michigan State University, USA

Time:11:20-11:40 Dec. 21
In-vivo Imaging Using Miniaturized Microscope

Assis. Prof. Zhen Qiu
Michigan State University, USA

Biography:

Zhen Qiu is an Assistant Professor in the Department of Biomedical Engineering, Institute for Quanti- tative Health Science and Engineering, Michigan State University, MI. He received the Ph.D. degree from the Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI. He finished his post-doctoral training in the Department of Radiology and Molecular Imaging Program Stanford (MIPS), School of Medicine, Stanford University, CA. His current research interests include biomedical optics, MEMS/MOEMS, multi-modal targeted imaging using novel contrast agents, wearable and implantable medical devices, ultrafast laser applications. He aims to study both cancer biology and translational medicine with custom-made micro-systems enabled ultra-thin in-vivo sensing/imaging tools. His work is mainly focused on miniaturized optical imaging system development for early cancer detection and imaging guided surgical navigation, such as wide-field imaging guided micro-scanner based confocal microendoscope, multi-photon/SHG handheld microscope, and SERS nanoparticles based Raman spectroscopy.
 

Abstract:

MEMS based microendoscopes have become important imaging tools for early cancer diagnosis and precise tumor resection. Due to various technical challenges, few microendoscopes have been translat- ed to clinics or applied to human patients. Through synergistic collaborations, we have developed novel MEMS scanner enabled microendoscopic multispectral (640nm to 780nm) three- dimensional dual-axis confocal fluorescent imaging system for translational applications, including early cancer detection and staging on colorectal cancer, molecular imaging guided surgical navigation on head and neck cancer. Based on dual-axis confocal microscopic architecture, we have miniaturized the imaging system with compact form-factor by integrating micro-optics and a patterned gold coated MEMS scanners, which have been custom-made and mass-produced in the nanofabrication foundry. The metal coating of the scanning mirror provides over 80% high reflectivity over near infra-red range. Both axes of the MEMS scanner could perform large tilting angle (> 6 degree mechanical scan angle) at DC and resonant mode. By advanced computational imaging approach, we have achieved real-time cross-sectional imaging in either raster or lissajous pattern scanning with fast frame rate (> 10 Hz) with large field-of-view (> 600 microns). Advanced real-time mosaicing algorithm has been developed to achieve broader view in milli- meter scale. By utilizing molecular contrast probes conjugated with fluorescence dye, we have success- fully demonstrated multi-spectral ex-vivo and in-vivo imaging on small animal tumor models and human tissue specimens, aimed for both early cancer detection and molecular imaging guided surgical naviga- tion.

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